Tricyclic antidepressants (TCAs) are a class of older-generation medications primarily used to treat major depressive disorder, certain anxiety disorders, chronic pain syndromes, neuropathic pain, migraine prophylaxis, insomnia, and obsessive-compulsive disorder. They work by inhibiting the reuptake of norepinephrine and serotonin at presynaptic neurons, thereby increasing the availability of...
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